Inspired by those 1980s kids’ toy TV advertisements, ‘Nanomachines’ explains genetics and targeted genetic treatments for Huntington’s disease in a fun and accessible format for kids of all ages! We at UCL Huntington’s Disease Centre developed this film in collaboration with UCLH NIHR Biomedical Research Centre and Greg Foot.
Author Archives: Ed Wild
HDSA Research Update 2020
In our annual roundup of what’s new and what’s hot in Huntington’s disease research for the Huntington’s Disease Society of America Annual Convention, Jeff Carroll and I talked about huntingtin lowering, the impact of covid-19 on HD research and much more. Featuring the world premiere of our ‘Nanomachines’ gene-silencing explainer!
The Gene: an Intimate History
In this feature-length PBS documentary by Oscar-winning director Ken Burns, I talked about our huntingtin-lowering clinical trial project .
Reading list for masters students, 2019
Byrne et al 2018
Evaluation of mutant huntingtin and neurofilament proteins as potential markers in Huntington’s disease
Science Translational Medicine 2018
Byrne et al 2017
Neurofilament light protein in blood as a potential biomarker of neurodegeneration in Huntington’s disease: a retrospective cohort analysis. Lancet Neurology 2017
Wild & Tabrizi 2017
Therapies targeting DNA and RNA in Huntington’s disease. Lancet Neurology 2017
Overview of huntingtin-lowering therapies in development.
Bates et al 2015
Huntington Disease. Nat Rev Disease Primers. 2015: 15005
Overview of HD biology, clinical features and therapeutic landscape
G Bates (textbook)
Huntington’s Disease (Oxford Monographs on Medical Genetics), 3rd ed. Ed G Bates, L Jones & S Tabrizi. Oxford University Press. ISBN 978-0199929146
Comprehensive monograph on HD
Wild & Tabrizi 2014
Targets for future clinical trials in Huntington’s disease: What’s in the pipeline? Mov Disord. 2014 Sep 15;29(11):1434-45. PMID: 25155142.
Therapeutic overview
Byrne, Rodrigues et al, Science Translational Medicine 2018: Evaluation of mutant huntingtin and neurofilament proteins as potential markers in Huntington’s disease
Guardian Science Weekly Podcast
Hannah Devlin speaks with Dr Ed Wild, from UCL, about Huntington’s and whether a new drug could slow its progression. And she hears from Roger, who was diagnosed with Huntington’s four years ago and his wife, Brenda.
Reading list for Masters Students 2018
Johnson et al 2018
Neurofilament light protein in blood predicts regional atrophy in Huntington disease. Neurology 2018
Byrne et al 2017
Neurofilament light protein in blood as a potential biomarker of neurodegeneration in Huntington’s disease: a retrospective cohort analysis. Lancet Neurology 2017
Wild & Tabrizi 2017
Therapies targeting DNA and RNA in Huntington’s disease. Lancet Neurology 2017
Overview of huntingtin-lowering therapies in development.
Bates et al 2015
Huntington Disease. Nat Rev Disease Primers. 2015: 15005
Overview of HD biology, clinical features and therapeutic landscape
G Bates (textbook)
Huntington’s Disease (Oxford Monographs on Medical Genetics), 3rd ed. Ed G Bates, L Jones & S Tabrizi. Oxford University Press. ISBN 978-0199929146
Comprehensive monograph on HD
Wild & Tabrizi 2014
Targets for future clinical trials in Huntington’s disease: What’s in the pipeline? Mov Disord. 2014 Sep 15;29(11):1434-45. PMID: 25155142.
Therapeutic overview
Al Arabiya Television Feature
Arabic language feature about the HTTRx trial program.
RTE Radio 1 Morning Ireland
BBC News at Ten: Huntington’s disease trial success
Huw Edwards discusses the IONIS-HTTRx trial success with Sarah Tabrizi and James Gallagher. Featuring footage of Ed Wild, Lauren Byrne and Filipe Brogueira Rodrigues.