Byrne et al 2018

Evaluation of mutant huntingtin and neurofilament proteins as potential markers in Huntington’s disease
Science Translational Medicine 2018

Byrne et al 2017

Neurofilament light protein in blood as a potential biomarker of neurodegeneration in Huntington’s disease: a retrospective cohort analysis. Lancet Neurology 2017

Wild & Tabrizi 2017

Therapies targeting DNA and RNA in Huntington’s disease. Lancet Neurology 2017
Overview of huntingtin-lowering therapies in development.

Bates et al 2015

Huntington Disease. Nat Rev Disease Primers. 2015: 15005
Overview of HD biology, clinical features and therapeutic landscape

G Bates (textbook)

Huntington’s Disease (Oxford Monographs on Medical Genetics), 3rd ed. Ed G Bates, L Jones & S Tabrizi. Oxford University Press. ISBN 978-0199929146
Comprehensive monograph on HD

Wild & Tabrizi 2014

Targets for future clinical trials in Huntington’s disease: What’s in the pipeline? Mov Disord. 2014 Sep 15;29(11):1434-45. PMID: 25155142.
Therapeutic overview

Here is the link to access the full text of this paper at Science Translational Medicine

Johnson et al 2018

Neurofilament light protein in blood predicts regional atrophy in Huntington disease. Neurology 2018

Byrne et al 2017

Neurofilament light protein in blood as a potential biomarker of neurodegeneration in Huntington’s disease: a retrospective cohort analysis. Lancet Neurology 2017

Wild & Tabrizi 2017

Therapies targeting DNA and RNA in Huntington’s disease. Lancet Neurology 2017
Overview of huntingtin-lowering therapies in development.

Bates et al 2015

Huntington Disease. Nat Rev Disease Primers. 2015: 15005
Overview of HD biology, clinical features and therapeutic landscape

G Bates (textbook)

Huntington’s Disease (Oxford Monographs on Medical Genetics), 3rd ed. Ed G Bates, L Jones & S Tabrizi. Oxford University Press. ISBN 978-0199929146
Comprehensive monograph on HD

 

Wild & Tabrizi 2014

Targets for future clinical trials in Huntington’s disease: What’s in the pipeline? Mov Disord. 2014 Sep 15;29(11):1434-45. PMID: 25155142.
Therapeutic overview

Because of an administrative delay in getting this review article available as open access, here is the PDF:

Targets for future clinical trials in Huntington’s disease: What’s in the pipeline?

Novak & Tabrizi 2011

Huntington’s Disease. BMJ 340:c3109

Ross & Tabrizi 2011

Huntington’s disease: from molecular pathogenesis to clinical treatment. Lancet Neurology 10:83-98.

Wild & Tabrizi 2007

The differential diagnosis of chorea. Practical Neurology 7:360.

Wild & Tabrizi 2007

Huntington’s disease phenocopy syndromes.
Current Opinion in Neurology 20:681.

G Bates

Huntington’s Disease, OUP. ISBN 978-0-19-851060-4

Hensman Moss D et al 2013

C9orf72 expansions are the most common genetic cause of Huntington disease phenocopies. Neurology.

This is a very simple VBA macro that counts the number of words in the current section of a Word document. It is very useful for grant applications or any document where you need to count the number of words in a particular passage rather than the whole document, without having to manually select the text.

Install it by pasting the code below into a new module in Word’s Visual Basic Editor.

You need to add section breaks before and after the text of interest.

I suggest assigning a shortcut key to the macro.

Sub SectionWordCount()
   Dim SectionWordCount As String

   SectionWordCount = ActiveDocument.Sections _
      (Selection.Information(wdActiveEndSectionNumber)). _
      Range.ComputeStatistics(wdStatisticWords)
   MsgBox "The current section has " & SectionWordCount & " words."

End Sub

It’s offered freely but I make no promises as to accuracy. Use it at your own risk.

This spreadsheet uses the Langbehn formula to calculate conditional onset probability in Huntington’s disease, based on CAG repeat length and the knowledge that a person has remained free of motor onset to a certain age.

It can be used to calculate an individual’s probability of onset after a given number of years, or the estimated time to a given probability of onset.

It also contains the formulae in a format that allows them to be pasted into other spreadsheets, allowing calculation of these parameters for multiple individuals.

These calculations are useful for research purposes only and are essentially meaningless for real people in real life. Use of this file is granted freely but subject to agreement that it will not be used to guide clinical or personal decisions, and that the user accepts full responsibility for its use. I also make no guarantee of accuracy – you should check these calculations yourself.

Please credit me if this file has been useful, and don’t forget to cite the awesome source publication. I’m happy to offer advice about its use, subject to availability of time.

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